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September 7, 2007

Ovarian cancer: The not-so-silent killer

Filed under: Uncategorized — Ashlynn @ 1:51 pm

ANN ARBOR, MI – Ovarian cancer doesn’t get the kind of attention breast cancer gets. It’s not as common, and because survival rates are poor, it does not produce an army of survivors to raise awareness. It’s traditionally known as the “silent killer” because it was thought to reveal no symptoms in its earliest, most curable stages.

But ovarian cancer is silent no more. First, researchers recently reported a cluster of symptoms that can indicate ovarian cancer. And advocates – both survivors and families – are beginning to make noise and encourage awareness for this disease.

September is Ovarian Cancer Awareness Month and on Sept. 7, people are encouraged to wear teal for “Teal Time Day”. Think of it as the ovarian cancer version of a pink ribbon. Advocates and researchers at the University of Michigan Comprehensive Cancer Center hope efforts like this will get people talking about ovarian cancer. What’s there to say? Start with these eight things you need to know:

1. Symptoms do exist. Bloating, pelvic or abdominal pain, difficulty eating, feeling full quickly, and frequent or urgent urinating are shown to be more common in women with ovarian cancer. These are vague symptoms and often mistaken for gastrointestinal problems. But if they persist for several days, get checked out by your gynecologist. “You can explain away these symptoms to yourself. But the only way to be sure it’s nothing is to go get a pelvic exam,” says J. Rebecca Liu, M.D., assistant professor of obstetrics and gynecology at the U-M Medical School and a gynecologic oncologist at the U-M Comprehensive Cancer Center.

2. There is no screening test for ovarian cancer, like a Pap smear or mammogram. The CA125 blood test measures the amount of a certain protein that’s often elevated with ovarian cancer. But the test is not foolproof. “There are a lot of benign conditions that can cause higher levels of CA125,” Liu says. Early detection is a key area of research. U-M researchers are looking for markers in the blood that indicate ovarian cancer, an approach that could in time lead to a blood test to screen for ovarian cancer.

3. All women need yearly pelvic exams. Maybe your doctor says you don’t need a Pap smear every year, but Pap tests just check for cervical abnormalities. A pelvic exam is not the same thing. In particular, older women should not discontinue their yearly gynecology visit as ovarian cancer is more likely to occur in women older than 60. “A pelvic exam is key because it’s the best screening we have right now,” Liu says.

4. Survival rates are significantly better when ovarian cancer is diagnosed in an early stage. With stage I ovarian cancer, the earliest stage, 95 percent of women are alive five years after diagnosis. Only 30 percent of women with stage III or IV ovarian cancer survive five years. More than 22,000 women will be diagnosed with ovarian cancer this year and more than 15,000 will die from the disease. Some 70 percent of women have advanced disease when they are diagnosed.

5. Ovarian cancer is difficult to treat because it’s often resistant to current treatments. It may respond to chemotherapy drugs initially, but when it recurs – which it usually does – the cells will no longer be killed by that drug. Researchers are focusing on new molecularly targeted therapies that hone in on and destroy the cancer cells, and they hope this will overcome the resistance. A new clinical trial recently opened to patient accrual at U-M looking at whether the drug Avastin, which has been successful for colon cancer, can improve survival in ovarian cancer.

6. It’s most common in older white women. Most patients are older than 60 and post-menopausal. Women who have not had children are at higher risk. Women who have taken birth control for a number of years lower their risk.

7. A small number of ovarian cancers are hereditary. It’s linked to the same genes that are linked to breast cancer, BRCA1 and BRCA2. If ovarian cancer runs in your family, particularly on your mother’s side, and if family members were diagnosed at a young age, you might consider genetic testing.

8. The best person to treat ovarian cancer is a gynecologic oncologist. These specialists are skilled in the comprehensive management of female reproductive cancers, including surgery and chemotherapy. Studies have shown gynecologic oncologists are two to three times more likely to provide surgical care consistent with national guidelines. Women with ovarian cancer treated by gynecologic oncologists have 10 percent to 25 percent better survival rates than women treated by general oncologists or gynecologists. While your regular gynecologist can perform diagnostic tests, if you are diagnosed with ovarian cancer, you should see a gynecologic oncologist.

Symptom check-list:

  • Bloating
  • Pelvic or abdominal pain
  • Difficulty eating or feeling full quickly
  • Urinary symptoms (urgency or frequency)
  • Symptoms are persistent and represent a change from the normal

Women who experience these symptoms almost daily for more than a few weeks should visit their regular gynecologist.

University of Michigan Comprehensive Cancer Center
U-M Cancer AnswerLine: 800-865-1125
U-M Breast and Ovarian Cancer Risk Evaluation Program
National Cancer Institute
Ovarian Cancer National Alliance
Women’s Cancer Network

Written by Nicole Fawcett

Article Source: www.webwire.com
Posted: (WebWire) 9/6/2007 12:56:29 PM

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1 Comment »

  1. Novi, Michigan – October 27th, 3007 conference:Survivors’ Debate: The Past Decade in Ovarian Cancerhttp://ovariancancerdebate.blogspot.com/WHAT: Ovarian cancer survivors, Carolyn Benivegna (U.S.) and Sandi Pniauskas (Canada), announce the first ever Ovarian Cancer Survivors Debate. The two conferences are survivor-led and survivor-organized with debate and discussion surrounding the multitude of issues – the past and the present. Open and lively dialogue will be encouraged. Funding for these events has been primarily through the ovarian cancer surivors.WHO SHOULD ATTEND: All cancer survivors/caregivers, healthcare professionals, researchers, pharmacists and the general public are encouraged to attend and participate.WHERE/WHEN: #1: Sheraton Hotel, Novi, MI Sat. October 27th, 2007#2: Metropolitan Hotel, Toronto, ON Sat. November 3rd, 2007 Time: 10:00 am – 12:30 pm No cost to attend Ovarian cancer has the highest mortality rate of all gynecologic cancers. Ovarian cancer has no early detection test. The debate and ensuing open forum public discussions will include the specifics of disease-related issues including genetics, access to care and communications. Carolyn Benivegna is a nine year ovarian cancer survivor, a BRCA1 carrier and Founder/Board Member of OCAG-GC. Sandi Pniauskas is an eight ovarian cancer survivor with a genetic predisposition to Lynch Syndrome/Hereditary NonPolyposis Colorectal Cancer and a member of the Cochrane Collaboration. Ovarian cancer survivors Annamarie DeCarlo and Dr. Yi Pan, MD, PhD will co-moderate both events. Bridget Capo (R.N.) and Pamela J. West (R.N.) will provide support and collaborate with Benivegna and Pniauskas in formal publication of the event proceedings. “Our community is very pleased to offer this exciting open public forum without cost to participants and we encourage active dialogue. We value our professional and family caregivers, but have seen the need, over years, for our community of cancer patients to have open discussions on the real issues that affect their lives. Today, and for the future. We need to appreciate the past, so that we may effectively bring attention to the sufferings experienced in our community. Most importantly we need to escalate change.” Benivegna/Pniauskas

    Comment by Sandi Pniauskas — September 7, 2007 @ 5:46 pm

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